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Proactive Investors United Kingdom
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er/rd/so
Shire gains exclusive rights to Acceleron's molecules outside of North America for muscular disorders: Specialty biopharmaceutical company Shire (LSE:SHP, NASDAQ:SHPGY) has announced the expansion of its Human Genetic Therapies pipeline through the exclusive license, in markets outside of North America, for the activin receptor type IIB (ActRIIB) class of molecules being developed by Acceleron Pharma, a private biotechnology company based in Cambridge, Massachusetts. Under the terms of the agreement, Shire will make an upfront payment to Acceleron of $45 million. The collaboration between the two companies will initially investigate ACE-031, Acceleron's lead ActRIIB drug candidate, currently in a Phase 2a trial for the treatment of patients with Duchenne Muscular Dystrophy (DMD), a fatal orphan muscle disease with no current treatment. ACE-031 and other ActRIIB molecules also have the potential to be used in other muscular and neuromuscular disorders. Shire and Acceleron will work on a worldwide development program to advance ACE-031 into a global Phase 2/3 clinical program designed to demonstrate disease modification in DMD patients. Shire will use its Lexington, Massachusetts manufacturing facility to produce commercial supplies of the product for both parties. If marketing authorization is received, Acceleron will commercialize ACE-031 in the U.S. and Canada, and Shire has the exclusive right to commercialize the therapy in the rest of the world. Acceleron is eligible to receive additional development, regulatory and sales milestone payments of up to $165 million for the successful commercialization of ACE-031 in DMD and up to an additional $288 million for successful commercialization of other indications and molecules, and royalties on product sales. "The structure of this collaboration allows Acceleron to retain commercial rights in North America, with the opportunity to build a highly valuable business while collaborating with an ideal partner for ACE-031," said CEO of Acceleron John Knopf. The deal will expand Shire's pipeline into a new therapeutic area. Shire's 2010 outlook of adjusted earnings of $4.00 per ADS, which was recently announced in its second quarter earnings press release, is unchanged. DMD is a debilitating and fatal genetic disorder characterized by the progressive loss of muscle strength and function. It primarily affects boys and occurs in approximately 1 in every 3,500 live male births. It is caused by genetic mutations that result in the absence of dystrophin, a protein necessary to maintain the structural integrity of muscle fibers. ACE-031 is an investigational protein therapeutic designed to build muscle and increase strength by inhibiting signaling through a cell surface receptor called activin receptor type IIB (ActRIIB). Shire focuses its business on attention deficit hyperactivity disorder (ADHD), human genetic therapies (HGT) and gastrointestinal (GI) diseases. The company was up more than 2% on the Nasadaq to $68.54 as of 12:40pm ET on Thursday.
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in/ld/ho
Orosur Mining CFO Ignacio Salazar ups shareholding: Orosur Mining’s (LON:OMI, TSX-V:OMI) chief financial officer Ignacio Salazar has bought 50,000 shares in the company for C$0.395 each.Salazar now has an interest in 80,000 shares, which represents 0.12% of the company. So far September has been a strong month for Orosur, with the company achieving significant development milestones.Last week, the company revealed its feasibility study for its Arenal Deeps gold-silver project in Uruguay, which supported a six year mine life with an IRR (internal rate of return) of 32.3%.The price assumption for the study was US$1,000/oz, which is 20% less than the current spot price of US$1,250/oz.Total cash costs have been estimated at US$545/oz, while total life of mine capital and operating costs were put at US$24.7 million and US$73.4 million respectively. Net present value (NPV) with a 7% discount amounted to US$16.4 million.Payable gold has been estimated at 135,000 oz.“This feasibility study for Arenal Deeps is an important step for the company in our objective to extend the San Gregorio mine life in Uruguay while maintaining production levels at approximately 50-60,000 ounces of gold per annum," said chief executive David Fowler.“The initial investment in capital and skills will also allow additional underground reserves to be targeted at San Gregorio to further extend mine life.” Previously, on 1 September, Orosur reported a 1.04 million ounce (Moz) maiden NI43-101 gold resource for the Pantanillo Norte deposit in Chile.In the Measured and Indicated category, Pantanillo Norte has 1,049,071 ounces, with 47,093,000 tonnes grading 0.69 grams per tonne (g/t). There is also 5,166 ounces in the Inferred category, with 304,000 tonnes at 0.53g/t gold.
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on/ti/ra
Europa Oil & Gas welcomes Aurelian update on Romanian operations: Europa Oil & Gas Holdings (LON:EOG) greeted today’s operational update by Aurelian Oil & Gas (LON:AUL) which covered the Romanian operations they are cooperating on. The Romanian projects are being explored in partnership with Aurelian and the country’s state-owned natural gas producer, Romgaz. The proportionate interests in the prospects vary from block to block.On the Brodina concession Aurelian has upped the - high-case - GIIP (Gas Initially In Place) assessment from 400 billion cubic feet to 415Bcf. The assessment follows newly reprocessed seismic data, the incorporation of the Voitinel-1 test results and a review of results from Romgaz's adjacent concession.Furthermore, the company has identified a new prospect to the west of the Voitinel well, which indicates potential GIIP upside. The prospect was identified with the recently acquired 60km 2D data, as well as information from Romgaz's Paltinu-102/103 wells.Additional leads have also been identified on the Bacau and Cuejdiu concessions, following 200km of 2D seismic.At Bacau, the overthrust area of the block was surveyed for the first time. Aurelian confirmed that it has identified additional leads, and the survey will have been interpreted by the end of October 2010. Early interpretation of the Cuejdiu 2D survey identified three leads, for 50-100 mmbbls gross.Aurelian said it is “very encouraged” with the early indications, although more work is required to further define these leads into drillable prospects.In addition to the details provided by Aurelian today, Europe said it has been informed by the Operator, MND, that the Barchiz-1 exploration well, situated in the Brates Block, where Europa holds 20 percent, is anticipated to spud in late September. This prospect is situated close to and along trend with the Moinesti oilfields and will be the first thrust belt play well drilled in this part of the basin based on modern seismic data. It has potential for up to 30 mmbo reserves and if successful is one of several similar leads on the Brates licence that trend up towards the newly identified leads on the Cuejdiu Licence.Europe managing director Paul Barrett commented “It is very encouraging that the 2010 seismic data is already capable of identifying structural leads even at the early processing stages. It bodes well for the oil play exploration programme in this underexplored part of the 5 billion barrel fairway.”
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ci/en/er
AIM Market Wrap: It has been a busy news day at the junior end of the market, with several stocks showing big gains on London’s AIM market. That said, it no news at all for both Kefi Minerals (LON:KEFI) and Thor Mining (LON:THOR) to soar 25% higher. Finders Resources (LON:FND) jumped around 23%, after a high-grade gold find in Sumatra. Initial interpretation suggests that Finders could be at the top of a large gold system, which may have potential for additional discoveries at depth. Canadian metals explorer Landore Resources (LON:LND) and Europa Oil & Gas (LON:EOG) both surged around 15%. Europa was boosted by a positive update from its joint venture partner in Romania, Aurelian Oil & Gas (LON:AUL). At the partners’ Brodina concession, Aurelian upped its assessment of the prospective gas resource. The partners have also identified a number of new prospects and leads across their interests in Romania, following seismic data surveys. Specialist media software firm Zoo Digital (LON:ZOO) advanced almost 14% higher, with the news that a major Hollywood movie studio is going to use the company’s new iTunes toolkit to produce downloadable content. Herencia Resources (LON:HER) added almost 12%. This afternoon the company released a positive half-yearly financial report. European Nickel (LON:ENK, ASX:ENK) non-executive director Neil Herbert bought 900,000 shares in the company at £0.24 each. The shares were up almost 9% today. Diamondcorp (LON:DCP), Horizonte Minerals (LON:HZM) and Shanta Gold (LON:SHG) each added 6%. Kalahari Minerals (LON:KAH) moved up nearly 5%, after its 41.15%-owned associate Extract Resources’ (ASX:EXT, TSX:EXT, NSX: EXT) reported a possible high-grade extension to the world-class Rössing South uranium deposit in Namibia. Cluff Gold (LON:CLF) rose by 2%, the company said it remains on track to produce 100,000oz of gold in 2010. In its first half trading update, the company revealed a 56% year-on-year increase in gold production to 52,109oz. Gulfsands Petroleum’s (LON:GPX) told investors that it may significantly increase daily production from the Yousefieh oilfield in Syria, after the completion of a horizontal development well. Meanwhile, in the 'Big-cap' area, the FTSE100 has climbed progressively throughout the day, reaching a 4-month high at 5,505. Thursday’s rally saw the FTSE100 gain 1.5%, up 76pts. The Bank of England had no surprises for investors, and the rate decision came and went with little fuss. The Monetary Policy Committee (MPC) voted to hold the key lending rate at 0.5 percent - the level it has now held for the 18months running. The banks and miners led the rally, accounting for 7 of the top 10 risers. The notable exception was ARM Holdings (LON:ARM), as the specialist semi-conductor group continued its strong recent form – which has largely been driven by a new product launch. ARM advanced almost 6%, to trade at an intraday high of 416p per share. Barclays (LON:BARC) gained over 5%, at 323.65p, followed by Vedanta (LON:VED), Xstrata (LON:XTA), Royal Bank of Scotland (LON:RBS) and Lloyds (LON:LLOY) who all rose around 3.5%. BP (LON:BP) followed the market high climbing almost 1.5%, despite coming under fire in the latest PR-tussle in America. Yesterday’s internal report on the Gulf of Mexico oil spill tried to apportion some of the blame on some of the other company’s involved with the Macondo well, and the explosion of Transocean’s Deepwater Horizon rig. American politicians, environmentalist group’s and, predictably, Halliburton and Transocean have since spoken out in disagreement with the oil giant’s claim. Also, BP confirmed that Hayward is due in front of the UK government’s Energy and Climate Change Select Committee next week, on the 15th September. Elsewhere, on the leader board Renishaw (LON:RSW) jumped over 15%, adding 128p to trade at £10.05. The specialist technology firm was buoyed by a ‘very positive’ start to the new financial year, which has seen ‘strong demand’ for Renishaw’s metrology products. Fenner (LON:FENR) and Premier Farnell (LON:PFL) were are up strongly, each gaining around 6.5%. Among the London’s ‘losers’, Home Retail (LON:HOME) slid almost 4% after it warned that full-year profits would be between 20-25% lower than expected, falling within the ‘bottom half of the current analyst range’, at around £250-275m. Thursday’s other notable fallers include Aveva (LON:AVV), which dropped 5%, as well as Redrow (LON:RDW) and Yell (LON:YELL) dropping around 3% each.
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yd/lo/ L
London Market Wrap : The FTSE100 has climbed progressively throughout the day, reaching a 4-month high at 5,505. Thursday’s rally saw the FTSE100 gain 1.5%, up 76pts.The Bank of England had no surprises for investors, and the rate decision came and went with little fuss. The Monetary Policy Committee (MPC) voted to hold the key lending rate at 0.5 percent - the level it has now held for the 18months running.The banks and miners led the rally, accounting for 7 of the top 10 risers. The notable exception was ARM Holdings (LON:ARM), as the specialist semi-conductor group continued its strong recent form – which has largely been driven by a new product launch.ARM advanced almost 6%, to trade at an intraday high of 416p per share.Barclays (LON:BARC) gained over 5%, at 323.65p, followed by Vedanta (LON:VED), Xstrata (LON:XTA), Royal Bank of Scotland (LON:RBS) and Lloyds (LON:LLOY) who all rose around 3.5%.BP (LON:BP) followed the market high climbing almost 1.5%, despite coming under fire in the latest PR-tussle in America. Yesterday’s internal report on the Gulf of Mexico oil spill tried to apportion some of the blame on some of the other company’s involved with the Macondo well, and the explosion of Transocean’s Deepwater Horizon rig.American politicians, environmentalist group’s and, predictably, Halliburton and Transocean have since spoken out in disagreement with the oil giant’s claim.Also, BP confirmed that Hayward is due in front of the UK government’s Energy and Climate Change Select Committee next week, on the 15th September.Elsewhere, on the leader board Renishaw (LON:RSW) jumped over 15%, adding 128p to trade at £10.05. The specialist technology firm was buoyed by a ‘very positive’ start to the new financial year, which has seen ‘strong demand’ for Renishaw’s metrology products.Fenner (LON:FENR) and Premier Farnell (LON:PFL) were are up strongly, each gaining around 6.5%.Among the London’s ‘losers’, Home Retail (LON:HOME) slid almost 4% after it warned that full-year profits would be between 20-25% lower than expected, falling within the ‘bottom half of the current analyst range’, at around £250-275m.Thursday’s other notable fallers include Aveva (LON:AVV), which dropped 5%, as well as Redrow (LON:RDW) and Yell (LON:YELL) dropping around 3% each.It has been a busy news day at the junior end of the market, with several stocks showing big gains on London’s AIM market.That said, it no news at all for both Kefi Minerals (LON:KEFI) and Thor Mining (LON:THOR) to soar 25% higher.Finders Resources (LON:FND) jumped around 23%, after a high-grade gold find in Sumatra. Initial interpretation suggests that Finders could be at the top of a large gold system, which may have potential for additional discoveries at depth.Canadian metals explorer Landore Resources (LON:LND) and Europa Oil & Gas (LON:EOG) both surged around 15%.Europa was boosted by a positive update from its joint venture partner in Romania, Aurelian Oil & Gas (LON:AUL). At the partners’ Brodina concession, Aurelian upped its assessment of the prospective gas resource. The partners have also identified a number of new prospects and leads across their interests in Romania, following seismic data surveys.Specialist media software firm Zoo Digital (LON:ZOO) advanced almost 14% higher, with the news that a major Hollywood movie studio is going to use the company’s new iTunes toolkit to produce downloadable content.Herencia Resources (LON:HER) added almost 12%. This afternoon the company released a positive half-yearly financial report.European Nickel (LON:ENK, ASX:ENK) non-executive director Neil Herbert bought 900,000 shares in the company at £0.24 each. The shares were up almost 9% today.Diamondcorp (LON:DCP), Horizonte Minerals (LON:HZM) and Shanta Gold (LON:SHG) each added 6%.Kalahari Minerals (LON:KAH) moved up nearly 5%, after its 41.15%-owned associate Extract Resources’ (ASX:EXT, TSX:EXT, NSX: EXT) reported a possible high-grade extension to the world-class Rössing South uranium deposit in Namibia.Cluff Gold (LON:CLF) rose by 2%, the company said it remains on track to produce 100,000oz of gold in 2010. In its first half trading update, the company revealed a 56% year-on-year increase in gold production to 52,109oz.Gulfsands Petroleum’s (LON:GPX) told investors that it may significantly increase daily production from the Yousefieh oilfield in Syria, after the completion of a horizontal development well.
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Proactive Investors United Kingdom
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09/09/10
Shire gains exclusive rights to Acceleron's molecules outside of North America for muscular disorders
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09/09/10
Orosur Mining CFO Ignacio Salazar ups shareholding
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09/09/10
Europa Oil & Gas welcomes Aurelian update on Romanian operations
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09/09/10
AIM Market Wrap: KEFI Minerals, Thor Mining, Landore, Europa Oil & Gas, Zoo Digital, Herencia
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09/09/10
London Market Wrap : ARM Holdings, Barclays, Vedanta, RBS, Lloyds
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Proactive Investors Australia
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09/09/10
Red Rock says the Jupiter Mines steel feed project clears a crucial hurdle
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09/09/10
Kalahari notes emergence of new uranium zone at Extract’s Rössing South deposit
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09/09/10
Kenmare Resources to join FTSE 250 index
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09/09/10
European Nickel director Neil Herbert buys 900,000 shares in co
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09/09/10
Sacre-Coeur's stock up 31% as it receives potential takeover bid
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09/09/10
Tethys signs document of understanding with Uzbek state company for Uzbekistan oil fields
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09/09/10
Regal Petroleum abandons exploration well in Romania, reviewing assets in the country
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09/09/10
Advanced Computer Software sees first-half EBITDA ahead of market expectations
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09/09/10
Antares Energy first well in Texas completed by Petrohawk
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09/09/10
NGM Resources shareholders take up Paladin takeover offer
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Proactive Investors US & Canada
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09/09/10
Sona Resources' 3,000m surface diamond drilling program at Elizabeth Gold property underway
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09/09/10
Camino Minerals Completes First Phase of Exploration at Four Properties in Mexico
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09/09/10
Halo Resources announces start of 1,250 metre drill program at Lost deposit in Manitoba
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09/09/10
Waytronx restructures and cuts size of term note related to acquisition of CUI
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09/09/10
Santarus soars 14% on distribution and licensing agreement for type 2 diabetic drug
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09/09/10
3M Acquires Patient Warming Products Manufacturer Arizant For $810M
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09/09/10
Stantec continues acquisition spree, announces ninth buy this year with Burt Hill
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09/09/10
Orosur Mining`s CFO snaps up 50,000 shares in company
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09/09/10
Shire gains exclusive rights to Acceleron's molecules outside of NA that treat muscular disorders
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09/09/10
China HGS Real Estate To List On The NASDAQ